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Thrombotic Thrombocytopenia Purpura

Thrombotic Thrombocytopenia Purpura (TTP) is a severe, occlusive, microvascular “thrombotic microangiopathy” characterized by low platelet count, microvascular thrombi, red cell fragmentation, central nervous system disorders and renal complications. ADAMTS13, also known as von Willebrand Factor (vWF) cleaving protease, is a zinc metalloproteinase that cleaves ultra large (UL) vWF multimers within the A2 region of vWF. The UL-vWF multimers bind to receptors on platelets inducing platelet aggregation and formation of intravascular microthrombi. Studies have shown that low levels of ADAMTS13 activity are strongly associated with a diagnosis of TTP. Assessing the ADAMTS13 protein levels and the presence of ADAMTS13 autoantibodies presents a comprehensive overview of the patient, identifying the patient’s condition as congenital versus acquired TTP.

ACTIFLUOR™ ADAMTS13 Activity Assay

REF: 812 CE Marked, Health Canada Registered* REF: 812RUO RUO


REF: 813 CE MarkedHealth Canada Registered* REF: 813RUO RUO


REF: 814 CE MarkedHealth Canada RegisteredREF: 814RUO RUO